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    CSRS
    The material presented at the CSRS Annual Meetings has been made available by the Cervical Spine Research Society for educational purposes only. The material is not intended to represent the only, nor necessarily best method or procedure appropriate for the medical situations discussed, but rather is intended to present an approach, view, statement or opinion of the faculty which may be helpful to others who face similar situations. The CSRS disclaims any and all liability for injury or other damages resulting to any individual attending the annual meeting and for all claims which may arise out of the use of the techniques demonstrated therein by such individuals whether these claims shall be asserted by physician or any other person.
  • Does Patient Satisfaction Reflect Quantitative Pain and Function Measurements in Cervical Spine Surgery?

    Background Context: Patient satisfaction with surgical treatment is a common qualitative metric used in FDA IDE clinical trials to assess treatment effectiveness. Often administered as a self-assessed questionnaire, a measurement of patient satisfaction gives an important evaluation of treatments success from a patient’s perspective. The extent to which patient satisfaction reflects more quantitative clinical outcome measures of pain and function has not been well characterized.
  • Intrathecal Administration of Recombinant Human Hepatocyte Growth Factor for Acute Spinal Cord Injury: Road from Bench to Clinical Trial and Future Perspective

    Introduction: Hepatocyte growth factor (HGF) has been highlighted as a potent organotrophic and angiogenic factor in the central nervous system, as well as in other solid organs. We first revealed that endogenous up-regulation of HGF in injured spinal cord was insufficient, compared with sharp increase of c-Met (HGF receptor) expression during acute phase of spinal cord injury (SCI) and introduction of exogenous HGF into spinal cord by HSV injection significantly promoted the survival of neurons and oligodendrocytes, angiogenesis and axonal regeneration, thereby reducing the damaged area and promoting functional recovery after SCI. We have also reported efficacy of intrathecal infusion of recombinant human HGF (rhHGF) in thoracic SCI model of rats and cervical SCI model of non-human primate (common marmoset).
  • Number of Operative Levels Minimally Impacts Risk for Adverse Events following an Anterior Cervical Decompression and Fusion

    Introduction: Little is known regarding the impact of the number of operative levels on the risk for adverse events following spinal procedures. The present study tests for associations between the number of operative levels and occurrence of adverse events following an anterior cervical decompression and fusion (ACDF). Materials/Methods: Patients undergoing one-, two-, or three-level ACDF were identified in the American College of Surgeons National Surgical Quality Improvement Program database.
  • 540° Cervical Realignment Procedure for Extensive Cervical OPll with Kyphotic Deformity

    Introduction: Decision of surgical strategy for extensive cervical OPLL with kyphotic deformity is highly controversial. Neurological injury and dural defect would be complications of anterior surgery and poor clinical outcomes caused by incomplete decompression would be problems of posterior approach. The authors performed a novel, two staged posterior-anterior-posterior (540°) procedure to get a realignment of the cervical spine and neural decompression to overcome the shortcomings of conventional procedures.  The purpose of this study is to present outcomes and feasibility of 540° procedures for extensive cervical OPLL with kyphotic deformity.
  • Sagittal Imbalance Might Be a Risk Factor of Increasing Post Laminoplasty Kyphosis

    Introduction: The cervical sagittal changes that occur after laminoplasty have been documented in numerous studies. Many studies reported risk factors of kyphotic change after laminoplasty; one particular study utilized T1 slope as a reference for this. However, these are only regional measurements and don’t include the overall spinal alignment.  Furthermore, T1 slope is very difficult to identify on lateral x-ray. The aim of this study was to analyze the change of sagittal cervical alignment after laminoplasty and to determine the correlation of changes on C2-C7 sagittal alignment and whole spinal sagittal parameters preoperative and post-laminoplasty.
  • Cervical Total Disc Replacement and Anterior Cervical Discectomy and Fusion have Similar Short-Term Complication Rates

    Introduction: Anterior cervical discectomy and fusion (ACDF) is currently the standard of care for treating many cervical spine pathologies, and has had high clinical success.  Cervical total disc replacement (CTDR) is a newer technology that is considered for similar indications as ACDF, with the potential benefit of maintaining motion while allowing decompression. While several studies have compared outcomes between these two interventions, this research has generally been limited by sample sizes. There is a need to compare short-term outcomes between these two procedures using a national cohort of patients in order to evaluate the safety of CTDR.
  • PROMIS Physical Function: A Better Patient Reported Outcome Measure in Cervical Spine Patients

    Introduction: High quality patient reported outcome (PRO) measures are needed for better understanding patient response to treatment of cervical disorders and for comparative effectiveness studies. There are significant concerns about the Neck Disability Index (NDI) regarding its validity, as currently used, and its psychometric properties (coverage in particular). Better measures are required. The NIH funded PROMIS Physical Function domain, delivered by Computerized Adaptive Testing (PF CAT) has been shown to outperform other disease specific measures in the spine patient population, though assessment specifically in patients with cervical spine disorders and direct comparisons with legacy measures have not been performed.