• MRI EVALUATION OF ACUTE CERVICAL INJURIES

    INTRODUCTION: The evaluation of acute cervical injuries typically consists of radiographs to determine the presence of a fracture or dislocation. Flexion/extension radiographs can demonstrate ligamentous injuries in certain cases, however, there is considerable controversy regarding their reliability and safety. Magnetic Resonance Imaging (MRI) has the ability to define the ligaments, discs, and soft tissues in the cervical area without manipulation of the neck and can be used in comatose or unresponsive patients. The purpose of this study was to determine the clinical utility of MRI studies in the evaluation of acute cervical injuries. METHODS: Eighty-seven patients initially seen in the emergency department at a level one trauma center who had possible cervical injuries and inconclusive radiographs were evaluated with MRI and included into the study.
  • RELATIONSHIP BETWEEN SPINAL-CORD DEFORMATION AND NEUROLOGICAL DEFICIT IN POST-REDUCTION CERVICAL-SPINE INJURIES

    INTRODUCTION: The mechanisms leading to the deleterious effects of severe spinal-cord injury are complex and multifactorial. Neurological deficit may stem from the initial insult to the cord or from secondary effects such as ischemia, hemorrhage, and/or edema. Our study examined the relationship between the severity of neurological deficit in cervical-spine injuries and the degree of post-reduction spinal-cord deformation. METHODS: We reviewed MRI scans and medical charts of patients with cervical spine injuries admitted to Harborview Medical Center between January 1995 and February 1997.
  • ARTHRODESIS FROM SYNERGISTIC COMBINATIONS OF BONE SUBSTITUTES AND INTERBODY FUSION CAGES

    INTRODUCTION: The integration of two technologies, interbody fusion cages and osteopromotive bone substitutes, has lead to a synergistic method of promoting arthrodesis after anterior cervical discectomy. Traditionally, bone grafts have been harvested from the iliac crest but the possibility of donor site morbidity or insufficient quantities have been among the key factors in the research and development of osteopromotive bone substitutes. At the forefront of this technology is rhBMP-2. In addition, the osteopromotive properties of a 15 sequence amino acid peptide, P15, has recently been shown to illicit promising osteopromotive behavior when coupled with hydroxyapatite granules. The Alpine cervical goat model has proven to be an aggressive animal model for examining the healing of fusions using bone grafts, instrumentation, or bone substitutes.
  • INITIAL EXPERIENCE WITH ENDOSCOPIC POSTERIOR CERVICAL LAMINOFORAMINOTOMY FOR THE TREATMENT OF CERVICAL RADICULOPATHY

    The initial experience with 24 patients with cervical radiculopathy secondary to cervical disc herniations treated utilizing an endoscopic posterior cervical laminoforaminotomy is presented. The procedure was modified from the traditional Scoville type with the addition of a paramedian muscle splitting approach and endoscopic visualization. Sixteen males and eight females were involved in the initial series. Only patients with single level symptoms refractory to conservative therapy and MRI or CT imaging confirming a corresponding lateral or foraminal lesion were considered. The series consisted of 8 C-5/6, and 16 C-6/7 lesions, 16 of these occurring on the left and 8 on the right.
  • AGE RELATED CHANGES IN APOPTOTIC RATE IN THE MURINE INTERVERTEBRAL DISC

    RELEVANCE TO MUSCULOSKELETAL CONDITIONS: The role of aging in the etiology of disc degeneration is not fully understood. Apoptosis (programmed cell death) may play an important role in this process.  The current study examines the relation of aging to the apoptotic index and the distribution of cells undergoing apoptosis in intervertebral discs. INTRODUCTION: Intervertebral discs undergo age-related degenerative changes. There are numerous factors involved in disc degeneration, such as declining nutrition, loss of viable cells, cell senescence, post-translational modification of matrix proteins, accumulation of degraded matrix molecules, and fatigue failure of the matrix to name a few. Apoptosis may be a major cause of disc degeneration and also a possible “common pathway” for other effecting processes. Therefore, we chose to study the trends of apoptotic index in relation to age in an animal model.