• Cervical Anterolisthesis is a Significant Poor Predictor of Neurologic Outcomes in Patients with Cervical Spondylotic Myelopathy following Cervical Laminoplasty

    Introduction: Several risk factors, including age, duration of myelopathic symptoms, diabetes, degree of cervical canal stenosis, and cervical alignment, have been identified for poor neurological outcomes in cervical spondylotic myelopathy (CSM) patients after cervical laminoplasty. However, few studies have focused on the surgical outcomes in CSM patients with cervical spondylolisthesis. Our objective was to clarify the influence of cervical spondylolisthesis on neurological outcomes in CSM patients after cervical laminoplasty. Materials and Methods: We retrospectively reviewed 125 CSM patients (86 men and 39 women) following cervical laminoplasty at our institute from January 1991 to June 2012.
  • Adjacent Segment Range of Motion does not Increase Two-Years after Single-Level Cervical Arthrodesis

    Introduction: The purpose of this longitudinal study was to determine if adjacent segment motion progressively increases following single-level anterior cervical discectomy and fusion (ACDF).  It was hypothesized that adjacent segment range of motion (ROM) would increase with time post-surgery, and that adjacent segment ROM 2 years post-surgery would be significantly greater than ROM at corresponding motion segments in agematched controls. Methods: Eight C5-C6 ACDF patients (1 M, 7 F; Age = 45 ± 9 years, tested 7 ± 1 months and 28±6 months post-surgery) and ten asymptomatic controls...
  • Does Patient Satisfaction Reflect Quantitative Pain and Function Measurements in Cervical Spine Surgery?

    Background Context: Patient satisfaction with surgical treatment is a common qualitative metric used in FDA IDE clinical trials to assess treatment effectiveness. Often administered as a self-assessed questionnaire, a measurement of patient satisfaction gives an important evaluation of treatments success from a patient’s perspective. The extent to which patient satisfaction reflects more quantitative clinical outcome measures of pain and function has not been well characterized.
  • Intrathecal Administration of Recombinant Human Hepatocyte Growth Factor for Acute Spinal Cord Injury: Road from Bench to Clinical Trial and Future Perspective

    Introduction: Hepatocyte growth factor (HGF) has been highlighted as a potent organotrophic and angiogenic factor in the central nervous system, as well as in other solid organs. We first revealed that endogenous up-regulation of HGF in injured spinal cord was insufficient, compared with sharp increase of c-Met (HGF receptor) expression during acute phase of spinal cord injury (SCI) and introduction of exogenous HGF into spinal cord by HSV injection significantly promoted the survival of neurons and oligodendrocytes, angiogenesis and axonal regeneration, thereby reducing the damaged area and promoting functional recovery after SCI. We have also reported efficacy of intrathecal infusion of recombinant human HGF (rhHGF) in thoracic SCI model of rats and cervical SCI model of non-human primate (common marmoset).
  • Number of Operative Levels Minimally Impacts Risk for Adverse Events following an Anterior Cervical Decompression and Fusion

    Introduction: Little is known regarding the impact of the number of operative levels on the risk for adverse events following spinal procedures. The present study tests for associations between the number of operative levels and occurrence of adverse events following an anterior cervical decompression and fusion (ACDF). Materials/Methods: Patients undergoing one-, two-, or three-level ACDF were identified in the American College of Surgeons National Surgical Quality Improvement Program database.
  • 540° Cervical Realignment Procedure for Extensive Cervical OPll with Kyphotic Deformity

    Introduction: Decision of surgical strategy for extensive cervical OPLL with kyphotic deformity is highly controversial. Neurological injury and dural defect would be complications of anterior surgery and poor clinical outcomes caused by incomplete decompression would be problems of posterior approach. The authors performed a novel, two staged posterior-anterior-posterior (540°) procedure to get a realignment of the cervical spine and neural decompression to overcome the shortcomings of conventional procedures.  The purpose of this study is to present outcomes and feasibility of 540° procedures for extensive cervical OPLL with kyphotic deformity.
  • The Incidence of an Epidural Hematoma following Cervical Spine Surgery

    Introduction: One of the most devastating complications that can occur after a cervical spine surgery is an epidural hematoma, which can lead to irreversible neurological injury without prompt attention and treatment. However, if this complication is recognized quickly and the hematoma is evacuated, patients can make a full recovery. For surgeons to be able to accurately inform their patients on the risks and benefits of cervical spine surgery, it is important to establish the actual incidence of rare but potentially devastating complications such as a postoperative epidural hematoma.
  • Sagittal Imbalance Might Be a Risk Factor of Increasing Post Laminoplasty Kyphosis

    Introduction: The cervical sagittal changes that occur after laminoplasty have been documented in numerous studies. Many studies reported risk factors of kyphotic change after laminoplasty; one particular study utilized T1 slope as a reference for this. However, these are only regional measurements and don’t include the overall spinal alignment.  Furthermore, T1 slope is very difficult to identify on lateral x-ray. The aim of this study was to analyze the change of sagittal cervical alignment after laminoplasty and to determine the correlation of changes on C2-C7 sagittal alignment and whole spinal sagittal parameters preoperative and post-laminoplasty.