• FOLLOW UP STUDY OF CONSERVATIVE TREATMENT FOR ATLANTO-AXIAL ROTATORY FIXATION

    INTRODUCTION: The subluxation of the atlanto-axial joint is well known as one of the causes of torticollis in children, and an irreducible case is distinguished as an atlanto-axial rotatory fixation (AARF). There have been many cases reported of AARF with several kinds of operative therapy, however few reports in the literature have described the prognosis after conservative treatment. The objective of this investigation is to reveal the prognosis of AARF after conservative treatment. METHODS: Diagnosis of the condition was made based on well-known physical signs as described by Fielding (cock robin position in association with diminished range of motion with muscle spasm) and by characteristic asymmetry of atlantoaxial joint on open mouth anteroposterior radiograph.
  • CERVICAL TRANSFACET VERSUS LATERAL MASS SCREWS: A BIOMECHANICAL COMPARISON

    BACKGROUND: Posterior cervical fixation with lateral mass plates is an accepted adjunctive technique for cervical spine fusions. Altered anatomy due to congenital malformation, tumor, trauma, infection, or failed lateral mass fixation may limit traditional screw placement options. Transfacet screw placement, which has been extensively studied in the lumbar spine, may offer an alternative when posterior cervical fusion is required. PURPOSE: To compare the pull-out strength of screws placed in the cervical lateral masses to that of screws placed across the facet joints.
  • ACTIVE KINEMATICS IN THE UPRIGHT CERVICAL SPINE AS DEMONSTRATED BYREAL-TIME MRI.

    The GE SIGNA SP OpenReal-Time MRI has recently been usedat our institution for the evaluation of cervical spine motionin normal adult volunteers The advantage of this systemisthe ability to accommodate a person in the upright sitting positionandits image acquisitiontime of 1 per second. This allowed for scanningof active flexion/extension of the cervical spine in the upright position. The aim of this study was to determine the segmental motion between flexion and extension of the cervical spine inthe upright loaded position.Ten volunteers were scanned in the GE SIGNA SP Open Real-Time MRI in order to assess the intervertebral motion of the cervical spine.
  • ADENOVIRUS-MEDIATED TRANSFER OF HUMAN TGF-1 ENCODING GENE TO THE RABBIT INTERVERTEBRAL DISC IN-VIVO UPREGULATES PROTEOGLYCAN SYNTHESIS

    INTRODUCTION: Disc degeneration and associated spinal disorders are a leading source of morbidity resulting in substantial pain and suffering and increased health care costs. Although the etiology and pathophysiology of intervertebral disc degeneration are largely unknown, few approaches are available clinically for the treatment or prevention of disc degeneration. Thompson and colleagues showed that addition of recombinant human TGF-β1 to canine disc tissue in culture could stimulate in-vitro proteoglycan synthesis, and they suggested that this growth factor might be used for the treatment of disc degeneration. Although recombinant growth factors have promising therapeutic properties, sustained delivery of the proteins to patients (especially for chronic conditions) would be difficult to accomplish with present technology.
  • THE USE OF BIORESORBABLE CAGES FOR ANTERIOR CERVICAL FUSION IN THE GOAT

    INTRODUCTION: The ideal device for the facilitation of bony fusion in the spine would provide structural support and stability for the interval during which bony growth transpires and then disappears once its presence was no longer needed. Such a device would necessarily have to withstand whatever loads were applied to it until replaced with bone; to resorb over an interval long enough to assure fusion but short enough not to prevent it; to resorb without producing an inflammatory response sufficient to impair fusion; and to produce no local chemical or pH changes sufficient to impair bone growth. Bioresorbable sutures made from various polylactide/polyglycolide polymers have been in clinical use for more than 30 years. Variations in the amino acid ratios of such polymers correspond to known variations in strength and in resorption rate.